Pharmacological characterization of alpha adrenoceptor‐mediated motor responses in the rat colon
Contractile responses in the circular muscle of the mid colon could be attributed to α-adrenoceptors located on enteric cholinergic neurons. Stimulation of α<sub>1A</sub>-adrenoreceptors activates SK<sub>Ca</sub> channels to cause smooth muscle relaxation, which constitutes a signaling pathway that shares similarities with P2Y<sub>1</sub> receptors.
Authors
- Marcel Jiménez (ORCID: https://orcid.org/0000-0002-6602-7332)
- Sara Traserra
- Francesc Jiménez‐Altayó (ORCID: https://orcid.org/0000-0002-9034-2041)
- Patri Vergara (ORCID: https://orcid.org/0000-0002-9220-6406)
- Marc Grao
- Sonia Trujillo
Institutions
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Centro de Investigación Biomédica en Red (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1111/nmo.14921
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitat Autònoma de Barcelona
- Agencia Estatal de Investigación