Application and efficacy of intestinal microbiota in pancreatic cancer treatment

<p indent="0mm">The human gut microbiota is abundant and generally maintains a relatively stable balance with the human body and the external environment. The intervention of intestinal microbiota in cancer treatment has shown a positive anti-cancer effect in a large number of studies. In recent years, increasing attention has been paid to pancreatic cancer due to its high rate of mortality. The treatments for this disease are not satisfactory, and they fail to improve the poor prognosis of patients. Therefore, targeting and regulating intestinal microbiota in a certain way to assist in the treatment of pancreatic cancer deserves attention. This review summarizes the correlation between intestinal microbiota and the tumor internal environment in the case of pancreatic cancer. It describes in detail the linkage between intestinal microbiota and cancer therapies, including immunotherapy, chemotherapy, prebiotic therapy, antibiotic treatment and fecal microbiota transplantation. The review also examines the impact of microbiome on the curative efficacy and looks into the future of the possible improvements in not only the curative effect of pancreatic cancer but also patients’ quality of life by applying innovative methods that emphasize treating cancer in the clinical environment with the assistance of gut microbiota adjustment.