Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection
In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism only when self-assembled into a Two-dimmensional supramolecular polymer (2D-SupraPol). Monomeric analogs of the dendritic polymer can only inhibit SARS-CoV-2 reversibly, thus allowing for the virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows a remarkable half-inhibitory concentration (IC<sub>50</sub> 30 nM) in vitro and in vivo in a Syrian Hamster model has a good efficacy. Using cryo-TEM, it is shown that the 2D-SupraPol has a controllable lateral size that can be tuned by adjusting the pH and use small angle X-ray and neutron scattering to unveil the architecture of the supramolecular assembly. This functional 2D-SupraPol, and its supramolecular architecture are proposed, as a prophylaxis nasal spray to inhibit the virus interaction with the respiratory tract.
Authors
- Ehsan Mohammadifar (ORCID: https://orcid.org/0000-0001-5720-5080)
- Chuanxiong Nie (ORCID: https://orcid.org/0000-0001-7963-1187)
- Francesco Stellacci (ORCID: https://orcid.org/0000-0003-4635-6080)
- Kai Ludwig (ORCID: https://orcid.org/0000-0001-6808-8107)
- Rainer Haag (ORCID: https://orcid.org/0000-0003-3840-162X)
- Mathias Dimde
- Thomas N. Zemb (ORCID: https://orcid.org/0000-0001-8410-6969)
- Tatyana L. Povolotsky (ORCID: https://orcid.org/0000-0001-5987-777X)
- Matteo Gasbarri (ORCID: https://orcid.org/0000-0002-8469-5369)
- Yannic Kerkhoff (ORCID: https://orcid.org/0000-0002-8126-2082)
- Sylvain Prévost (ORCID: https://orcid.org/0000-0002-6008-1987)
- Heyun Wang (ORCID: https://orcid.org/0000-0001-6764-4220)
- Daniel J.-M. Desmecht (ORCID: https://orcid.org/0000-0001-9440-0993)
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Liège (BE)
- Université de Montpellier (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Institut Laue-Langevin (FR)
- Institut de Chimie Séparative de Marcoule (FR)
- École Polytechnique Fédérale de Lausanne (CH)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1002/adma.202408294
- Citations
- 9
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- European Research Council