Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla
Creatine supplementation over six weeks in ME/CFS patients increased brain creatine and improved fatigue and some aspects of cognition. Despite its methodological limitations, this study encourages placebo-controlled investigations of creatine treatment in ME/CFS.
Authors
- Uzay E. Emir (ORCID: https://orcid.org/0000-0001-5376-0431)
- Beata R. Godlewska (ORCID: https://orcid.org/0000-0002-5973-3765)
- Marieke Martens (ORCID: https://orcid.org/0000-0003-0108-1327)
- Amy Sylvester (ORCID: https://orcid.org/0000-0001-6297-8432)
- Philip J. Cowen (ORCID: https://orcid.org/0000-0001-5518-6138)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- Ann L. Sharpley (ORCID: https://orcid.org/0000-0002-0623-1067)
Institutions
- University of North Carolina at Chapel Hill (US)
- Oxford Health NHS Foundation Trust (GB)
- Maastricht University (NL)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
Publication Details
- Journal
- Nutrients
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3390/nu16193308
- Citations
- 3
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council