Aspilactonol J: A New Cytotoxic Polyketide Isolated from the Marine-Derived Fungus Aspergillus sp. w2-13

Marine-derived Aspergillus sp.strain w2-13, isolated from Dongshan Island in Fujian Province, produced five compounds through solid-state fermentation.This included a new polyketide, aspilactonol J (1), and four previously identified compounds (2-5).The structure of the new compound was determined using NMR, HR-MS, and ECD, supported by theoretical calculations.A plausible biosynthetic pathway for polyketides 1-3 was also proposed.Cytotoxicity tests on various cancer cell lines revealed that aspilactonol J (1) exhibited significant selectivity and efficacy, especially against HepG2 cells, suggesting its potential for pharmaceutical development.This study highlights the role of marine fungi as valuable sources of bioactive natural products with therapeutic potential.