Clinical Presentation and Treatment Outcomes of Adult-Onset Coats Disease

<b>Purpose:</b> To study the clinical profile, treatment, and outcomes of patients 35 years or older diagnosed with Coats disease. <b>Methods:</b> A cross-sectional observational hospital-based study was performed. <b>Results:</b> The study included 74 eyes diagnosed with adult-onset Coats disease. The mean age at presentation was 50 years (range, 35-75). Most patients were men (72.5%) and had a unilateral presentation (92.8%). The most common stage at presentation was 2A (extrafoveal exudation [39.2%]) followed by 2B (foveal exudation [33.7%]). Optical coherence tomography was performed in 40 eyes; 32 eyes (80.0%) had intraretinal fluid (IRF), 31 eyes (77.5%) had hard exudates, and 22 eyes (55.0%) had a disorganized retinal inner layer. Fluorescein angiography was performed in 35 eyes and showed an irregular foveal avascular zone in 28 eyes (80.0%). Multiple leaking microaneurysms were seen in 32 eyes (91.4%), with extensive vascular abnormalities involving the macula (86%) and extramacular zones (91%). Treatment modalities comprised laser photoablation (43.4%), cryotherapy with or without laser application (5.7%), and intravitreal injections (49%), alone or in combination. At a mean follow-up of 28 months (range, 3-293), 23 eyes (39.6%) had anatomic resolution of subretinal fluid and/or IRF. No statistically significant improvement was found in the mean best-corrected visual acuity (VA) between preoperatively and postoperatively (<i>P</i> > .05). <b>Conclusions:</b> Patients with adult-onset Coats disease have a unilateral presentation with a less severe stage than patients with childhood-onset disease. Despite the good anatomic response after treatment, the final VA remained unchanged.