Temperature Simulation of an Ablation Needle for the Prediction of Tissue Necrosis during Liver Ablation

<b>Background/Objectives:</b> Microwave ablation (MWA) is the leading therapy method for treating patients with liver cancer. MWA simulation is used to further improve the therapy and to help develop new devices. <b>Methods:</b> A water-cooled ablation needle was reconstructed. MWA simulations of a polyacrylamide phantom were carried out and compared with a representative clinical example (tumor diameter: 8.75 mm). The Arrhenius damage model and a critical temperature approach of 60 °C were applied to assess the necrosis zones. Finally, the simulation results were compared to the corresponding MR measurements. <b>Results:</b> Most of the heating in the simulation took place at a distance of 5 mm along the transverse axis and 20 mm along the longitudinal axis above the needle tip. The calculated Dice scores for the Arrhenius model were 0.77/0.53 for the phantom/clinical case. For the critical temperature approach, Dice scores of 0.60/0.66 for the phantom/clinical case were achieved. <b>Conclusions:</b> The comparison between simulated and measured temperature increases showed an excellent agreement. However, differences in the predicted necrosis volume might be caused by omitting consideration of the heat sink effect, especially in the clinical case. Nevertheless, this workflow enables short MWA simulation times (approximately 3 min) and demonstrates a step towards possible integration into daily clinical use.

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Publication Details

Journal
Journal of Clinical Medicine
Published
2024-09-30
DOI
https://doi.org/10.3390/jcm13195853
Citations
6
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
1.11
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article

Temperature Simulation of an Ablation Needle for the Prediction of Tissue Necrosis during Liver Ablation

Sylvia Saalfeld, Daniel Düx, Philipp Berg, Thomas Gerlach et al.
6 citations
Journal of Clinical Medicine
Ultrasound and Hyperthermia Applications
1.11
article

Temperature Simulation of an Ablation Needle for the Prediction of Tissue Necrosis during Liver Ablation

Sylvia Saalfeld, Daniel Düx, Philipp Berg, Thomas Gerlach, Bennet Hensen, Georg Hille, Simon Schröer, Frank K. Wacker, Marcel Gutberlet, Maximilian Will
article en
6 citations

Abstract

<b>Background/Objectives:</b> Microwave ablation (MWA) is the leading therapy method for treating patients with liver cancer. MWA simulation is used to further improve the therapy and to help develop new devices. <b>Methods:</b> A water-cooled ablation needle was reconstructed. MWA simulations of a polyacrylamide phantom were carried out and compared with a representative clinical example (tumor diameter: 8.75 mm). The Arrhenius damage model and a critical temperature approach of 60 °C were applied to assess the necrosis zones. Finally, the simulation results were compared to the corresponding MR measurements. <b>Results:</b> Most of the heating in the simulation took place at a distance of 5 mm along the transverse axis and 20 mm along the longitudinal axis above the needle tip. The calculated Dice scores for the Arrhenius model were 0.77/0.53 for the phantom/clinical case. For the critical temperature approach, Dice scores of 0.60/0.66 for the phantom/clinical case were achieved. <b>Conclusions:</b> The comparison between simulated and measured temperature increases showed an excellent agreement. However, differences in the predicted necrosis volume might be caused by omitting consideration of the heat sink effect, especially in the clinical case. Nevertheless, this workflow enables short MWA simulation times (approximately 3 min) and demonstrates a step towards possible integration into daily clinical use.

Journal of Clinical MedicineVol. 13(19)
Christian-Albrechts-Universität zu Kiel (DE), Medizinische Hochschule Hannover (DE), University Hospital Magdeburg (DE)
Clean water and sanitation
Openalex Percentile: Top 24%
Ultrasound and Hyperthermia Applications
1.11
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