Water Participated Dual C(sp <sup>3</sup> )−C(sp <sup>3</sup> ) Bond Cleavage of Cyclobutanones Catalyzed by Lewis Acid
Abstract Lewis acid‐catalyzed ring‐opening reactions of cyclobutanones were mostly achieved through cleavage of a single C2−C3 bond to deliver cyclic products. Herein, an unprecedented Lewis acid catalyzed synergistic cleavage of both C2−C3 bonds in 3‐arylcyclobutanones was realized under participation of water, providing a series of aryl alkyl ketones in mild conditions. A broad scope of substrates decorated with various substituents were well accommodated. Mechanistic proposal including the function of water was unambiguously validated by experimental verification.
Authors
- Z Liu
- Yuanqi Wu (ORCID: https://orcid.org/0009-0003-3356-5921)
- Jie Tao (ORCID: https://orcid.org/0000-0002-2027-2287)
- Yu Liu (ORCID: https://orcid.org/0000-0003-1304-9498)
- Dongyue Zhang (ORCID: https://orcid.org/0000-0002-0697-4813)
- Tingting Li (ORCID: https://orcid.org/0000-0003-2294-1701)
- Wenhui Ma (ORCID: https://orcid.org/0000-0001-8828-4498)
- Tian‐Gui Li
Institutions
- Changchun University of Technology (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1002/slct.202402873
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- National Natural Science Foundation of China