Polyenylphosphatidylcholine alleviates cardiorenal fibrosis, injury and dysfunction in spontaneously hypertensive rats by regulating Plpp3 signaling
We identified a new protective role for PPC in mitigating cardiac and renal injuries associated with hypertension, as well as in preventing aortic fibrosis and remodeling. Targeting the NF-<i>κ</i>B/Plpp3 pathway may offer a promising therapeutic strategy for treating vascular diseases related to hypertension.
Authors
- Jiaxin Gong (ORCID: https://orcid.org/0009-0006-2650-8314)
- Yongqiao Zhang (ORCID: https://orcid.org/0009-0007-6886-9254)
- Wei Feng (ORCID: https://orcid.org/0000-0002-0048-4020)
- Zhuang Li (ORCID: https://orcid.org/0009-0008-6586-3989)
- Zhaoqiang Cui (ORCID: https://orcid.org/0000-0002-1150-1009)
- Ningzhi Zhang (ORCID: https://orcid.org/0000-0002-9570-4726)
- Jiayi Ma (ORCID: https://orcid.org/0000-0003-3264-3265)
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fcvm.2024.1458173
- Citations
- 5
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China