Impact of Aficamten on Disease and Symptom Burden in Obstructive Hypertrophic Cardiomyopathy
Treatment with aficamten was associated with substantial improvements across a broad range of clinically relevant efficacy measures. These results underscore the wide-ranging potential of aficamten for treatment of patients with symptomatic oHCM (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults with oHCM [SEQUOIA-HCM]; NCT05186818).
Authors
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0001-8966-6906)
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Artur Oręziak (ORCID: https://orcid.org/0000-0003-3318-3643)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- John A. Spertus (ORCID: https://orcid.org/0000-0002-2839-2611)
- Michelle Michels (ORCID: https://orcid.org/0000-0001-6432-0431)
- Michael Arad (ORCID: https://orcid.org/0000-0003-3723-7493)
- Gregory D. Lewis (ORCID: https://orcid.org/0000-0001-8108-8240)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Amy Wohltman
- Hugh Watkins (ORCID: https://orcid.org/0000-0002-5287-9016)
- Nuno Cardim (ORCID: https://orcid.org/0000-0002-3812-4872)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Brian Claggett
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Albert Hagège (ORCID: https://orcid.org/0000-0003-4685-6077)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Matthew M.Y. Lee (ORCID: https://orcid.org/0000-0001-9213-2067)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Ian J. Kulac (ORCID: https://orcid.org/0000-0002-0710-1088)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Lisa Meng (ORCID: https://orcid.org/0000-0003-0229-1131)
- Lubna Choudhury (ORCID: https://orcid.org/0000-0003-4039-8490)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- Marion van Sinttruije
- Changsheng Ma (ORCID: https://orcid.org/0000-0002-3612-7367)
- Josef Veselka (ORCID: https://orcid.org/0000-0003-3597-3155)
- Jacob Tfelt‐Hansen (ORCID: https://orcid.org/0000-0003-3895-9316)
- Hans‐Dirk Düngen
- James L. Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
Institutions
- Northwestern University (US)
- University of Copenhagen (DK)
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- Saint Luke's Health System (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Capital Medical University (CN)
- Sheba Medical Center (IL)
- Erasmus MC (NL)
- Copenhagen University Hospital (DK)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Lahey Medical Center (US)
- Baim Institute for Clinical Research (US)
- Viaa Christian University of Applied Sciences (NL)
- Meyer Children's Hospital (IT)
- Centro de Investigación Biomédica en Red (ES)
- Beijing Anzhen Hospital (CN)
- Institute of Cardiology (PL)
- Saint Luke's Hospital (US)
- Cytokinetics (United States) (US)
- Complexo Hospitalario Universitario A Coruña (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Klinikum Chemnitz (DE)
- Hospital do Desterro (PT)
- Hospital CUF Descobertas
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Pennsylvania (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.jacc.2024.09.003
- Citations
- 34
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.67
Funders
- Cytokinetics