Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3
Over-expression of histone H3K9me3 and H3K27me3 marks may be related to super-MTX resistance and to the loss of malignancy of super MTX-resistant osteosarcoma cells due to the fundamental relationship of methylation and cancer.
Authors
- Yutaro Kubota (ORCID: https://orcid.org/0000-0002-2917-8764)
- Yasunori Tome (ORCID: https://orcid.org/0000-0002-3716-1866)
- Kotaro Nishida (ORCID: https://orcid.org/0000-0002-1279-2717)
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- Koya Obara (ORCID: https://orcid.org/0000-0002-5235-3161)
- NORIYUKI MASAKI (ORCID: https://orcid.org/0000-0002-0463-9608)
- YUSUKE AOKI (ORCID: https://orcid.org/0000-0002-1701-9678)
Institutions
- University of the Ryukyus (JP)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.21873/anticanres.17251
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00