Therapeutic Responses to Two New SN-38 Derivatives in Colorectal Cancer Patient-Derived Xenografts and Respective 3D<i>In Vitro</i>Cultures
The new SN-38 derivatives, BN-MOA and BN-NMe, showed enhanced therapeutic effects compared to irinotecan in CRC models. BN-MOA demonstrated superior tumor inhibition in vivo, while BN-NMe had similar in vitro activity to SN-38. These findings highlight the potential of BN-MOA for greater antitumor efficacy in vivo, with BN-NMe showing comparable effectiveness to SN-38 in vitro. Future studies should optimize growth models to better predict anticancer drug responses.
Authors
- Justyna Kocik-Krol (ORCID: https://orcid.org/0000-0002-3779-3118)
- Katarzyna Unrug-Bielawska (ORCID: https://orcid.org/0000-0003-3453-1590)
- Jerzy Ostrowski (ORCID: https://orcid.org/0000-0003-1363-3766)
- Krzysztof Klimkiewicz (ORCID: https://orcid.org/0000-0002-1418-1020)
- David L. Earnshaw (ORCID: https://orcid.org/0000-0002-0650-1362)
- Magdalena Urbanowicz
- Zuzanna Sandowska-Markiewicz
- Beata Naumczuk (ORCID: https://orcid.org/0000-0003-3740-8387)
- Michał Mikuła (ORCID: https://orcid.org/0000-0003-3447-7328)
- Marcin Krzykawski (ORCID: https://orcid.org/0000-0002-0340-3134)
- Lech Kozerski (ORCID: https://orcid.org/0000-0003-3315-2193)
- Magdalena Cybulska (ORCID: https://orcid.org/0000-0002-1029-3156)
- Małgorzata Statkiewicz (ORCID: https://orcid.org/0000-0003-2170-1909)
- Izabela Rumieńczyk (ORCID: https://orcid.org/0000-0002-2957-8952)
- Ewelina Kaniuga (ORCID: https://orcid.org/0000-0002-2761-9685)
- Michalina Dąbrowska
Institutions
- Institute of Organic Chemistry (PL)
- National Institute of Oncology (HU)
- Postgraduate School of Molecular Medicine (PL)
- Krakow Cardiovascular Research Institute (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Narodowy Instytut Leków (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Anticancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.21873/anticanres.17252
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.85