Synthesis of the natural peptide product Fusahexin

The building block Fmoc-ehr=Pro-OH can be synthesized in a 9 step synthesis with the LEMIEUX-JOHNSON oxidation as the key step.With this dipeptide the synthesis of the peptide natural product fusahexin was possible and 10 mg were isolated as a white solid.Because of the similiarity to the dipeptide which BALDWIN & CLARIDGE proposed as a -turn mimic the Fmoc-ehr=Pro-OH building block is a possible -turn mimic.In further studies the building bock is going to be used in more different peptide sequences to see if it is introducing a -turn.Bioactivity studies are in progress. References Conclusion and Outlook Modeling