Flux-Screened Copper/Electric Dual-Catalyzed Chemo- and Enantioselective Ullmann-Type C–C Coupling Reactions
This study introduces an innovative copper/electric dual-catalyzed approach to Ullmann coupling reactions. Our research delineates a series of chemoselective cross-couplings among various halogenated aromatics and enantioselective couplings involving halogenated aryl aldehydes. We employed a flux screening technique to refine the reaction parameters, which is rarely reported in the field of electrochemical synthesis. This advancement accelerates the determination of optimal reaction conditions and affords some inspiration for developing sustainable and ecofriendly chemical synthesis.
Authors
- Shengyang Tao (ORCID: https://orcid.org/0000-0002-0567-8860)
- Yunhe Jin (ORCID: https://orcid.org/0000-0003-0626-4587)
- Yun Zou (ORCID: https://orcid.org/0000-0003-3015-2614)
- Jia Ying Xin
Institutions
- Dalian University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1021/acs.orglett.4c03196
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- Belarusian Republican Foundation for Fundamental Research
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities