Pelger-Huët Anomaly (PHA) Case Report

Pelger-Huët anomaly is a rare benign hematological disorder. It was first described in the 1920s. It is inherited in an autosomal dominant manner. Nuclear hypolobulation, which can also be seen in other leukocytes, especially neutrophils, is a characteristic feature. This morphological change does not cause a defect in the immune system. It should be differentiated clinically from pseudo-Pelger-Huët anomaly (PPHA). In this study, Pelger-Huët anomaly is presented which is noticed in the peripheral smear of a 22-year-old female patient who came to the hematology outpatient clinic due to her sibling having Hodgkin’s lymphoma. The family members of the case were also evaluated in this respect.