Iron TAMs: The fallen protectors
A new study by Folkert et al. (https://doi.org/10.1084/jem.20230420) defines an "iron-rich" subset of tumor-associated macrophages (iTAMs). The metabolism of heme leads to the degradation of the transcriptional repressor Bach1 and shapes the transcriptional profile of iTAMs. The endothelin receptor B in iTAMs signals tumor-supportive functions.
Authors
- Mikala Egeblad (ORCID: https://orcid.org/0000-0002-3371-1445)
- Lijuan Sun (ORCID: https://orcid.org/0000-0003-0080-7886)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1084/jem.20240951
- Citations
- 1
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.45