Profiling inflammatory outcomes of <i>Candida albicans</i> colonization and food allergy induction in the murine glandular stomach

Food allergy continues to be a growing public health concern, affecting at least 1 in 10 individuals in the United States alone. However, little is known about the involvement of the gastric mucosa in food allergy. Gastrointestinal <i>Candida albicans</i> colonization has been reported to promote gastrointestinal inflammation in a number of chronic diseases. Using a mouse model of food allergy to egg white protein, we demonstrate regionalization of the inflammatory response to <i>C. albicans</i> colonization, induction of robust type 2 (allergic) inflammation in the stomach, and augmentation of innate and type 3 responses by <i>C. albicans</i> colonization during food allergy.