Deletion of miR‐33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice
Loss of microRNA-33 (miR-33) increased ABCA1 protein levels and the lipidation of apolipoprotein E. Loss of miR-33 reduced amyloid beta (Aβ) levels, plaque deposition, and gliosis. mRNAs and proteins dysregulated by miR-33 loss relate to microglia and Alzheimer's disease. Inhibition of miR-33 increased microglial migration and Aβ phagocytosis in vitro.
Authors
- Yanwen You
- Byung-Wook Kim (ORCID: https://orcid.org/0000-0001-8390-7713)
- Mason D. Tate (ORCID: https://orcid.org/0000-0002-8967-4006)
- Emma H. Doud (ORCID: https://orcid.org/0000-0003-0049-0073)
- Cristian A. Lasagna‐Reeves (ORCID: https://orcid.org/0000-0002-5499-3082)
- Stéphanie Philtjens (ORCID: https://orcid.org/0000-0002-8004-2088)
- Megan Wells
- Jungsu Kim (ORCID: https://orcid.org/0000-0002-6931-8581)
- Carlos Fernández‐Hernando (ORCID: https://orcid.org/0000-0002-3950-1924)
- H. R. Sagara Wijeratne (ORCID: https://orcid.org/0000-0002-8209-5626)
- Amber L. Mosley (ORCID: https://orcid.org/0000-0001-5822-2894)
- Do‐Hun Lee (ORCID: https://orcid.org/0000-0001-6840-7841)
- Daniel Sharify
- Daniela Gutiérrez (ORCID: https://orcid.org/0000-0001-5823-8044)
- Magdalena Perez‐Cardelo
Institutions
- Yale University (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1002/alz.14243
- Citations
- 10
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.85
Funders
- American Diabetes Association
- National Institute on Aging