VIABILITY OF BLOOD LEUKOCYTES OF RATS AFTER IMPLANTATION OF POLYPROPYLENE SURGICAL MESH WITH A TANTALUM-BASED COATING AND ITS DERIVATIVES

Aim. To investigate the viability and types of cell death of peripheral blood leukocytes in experimental animals after implantation of surgical meshes with a tantalum-based coating and its derivatives. Materials and methods. The experimental group included 40 male rats of the WAG population. Polypropylene surgical mesh was surgically implanted between the abdominal wall and sections of the large intestine with different types of coatings. After 28 days, collected blood was analyzed by a BD FACSCanto™ II flow cytometer. Results. It was determined that there were no significant changes in the viability of blood leukocytes between the animals of the intact group and the group of animals that underwent surgery without implantation. Analysis of leukocyte viability in groups of rats implanted with tantalum and tantalum oxide-coated meshes showed a slight decrease in viable cells compared with the results of the intact group. At the same time, the percentage of necrotic cells showed a slight increase. In the group of rats implanted with a mesh with tantalum nitride-coated, a decrease in viable leukocytes was determined in comparison with the results of the intact group by 12,9%, while the percentage of necrotic leukocytes was 3,8% higher. A 16,2% decrease in viable leukocytes was determined in the group of rats implanted with a non-coated mesh compared to the results of the intact group. At the same time, the percentage of necrotic cells was 6,9% higher. Conclusions. Implantation of uncoated and tantalum nitride-coated surgical meshes was found to decrease the percentage of viable blood leukocytes in rats compared to intact animals, while implantation of tantalum- and tantalum-oxide-coated surgical meshes did not significantly decrease viable white blood cells. leukocytes.