Impacts of Matrix Metalloproteinase-8 Genotypes, Smoking, Alcohol Drinking, and<i>Helicobacter Pylori</i>Infection on Gastric Cancer
The findings indicate that individuals carrying the MMP-8 rs11225395 CC genotype have increased susceptibility to GCa, especially when combined with risk factors, such as smoking, alcohol consumption, and H. pylori infection. These results suggest that MMP-8 genotype-based preventive strategies, including lifestyle alterations and targeted infection treatments, may be valuable in mitigating GCa development.
Authors
- WEI-CHING CHIEN
- Chia-Wen Tsai (ORCID: https://orcid.org/0000-0002-8324-6596)
- Tao‐Wei Ke (ORCID: https://orcid.org/0000-0001-6847-4008)
- Jaw‐Chyun Chen (ORCID: https://orcid.org/0000-0001-8468-5702)
- Yi‐Chih Hung (ORCID: https://orcid.org/0000-0002-2464-7779)
- WEN-SHIN CHANG (ORCID: https://orcid.org/0000-0003-1735-2857)
- Ying-Jing Chen
- DA-TIAN BAU
- Mei-Due Yang
- Chun-Kai Fu
Institutions
- Dayeh University (TW)
- Asia University (TW)
- China Medical University (TW)
- Taichung Veterans General Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- China Medical University Hospital (TW)
- Taichung Armed Forces General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.21873/anticanres.17253
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- China Medical University Hospital
- China Medical University
- Taichung Veterans General Hospital
- Chang Bing Show Chwan Memorial Hospital
- Division of Materials Research