Development of a HPMC-patch containing RGD and KTTKS peptide sequences for application in tissue healing
The peptide-loaded film were successfully obtained using a modified peptide from natural human fibronectin containing the RGD and KTTKS sequences.The addition of the peptide to didn't show significantly changes on film chemical or physical properties but increased positively the cytotoxicity, proliferation and antimicrobial activity in comparison to the behavior of the free peptide.In general, the peptide-loaded film is very promising for use in biomedical applications, especially in cutaneous tissue healing as a transdermal patch.
Authors
- Reinaldo Marchetto (ORCID: https://orcid.org/0000-0002-8757-321X)
- Naiara Maia Pereira (ORCID: https://orcid.org/0000-0002-8444-9408)
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1144
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00