Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma
DCPS is a promising target for GBM. Inhibition of DCPS with RG3039 at doses achievable in humans downregulates STAT5B expression and reduces proliferation, survival and colony formation of GBM cells. Given the excellent anti-cancer activity and central nervous system bioavailability in vivo and good tolerance in humans, RG3039 warrants further study as a potential GBM therapy.
Authors
- Haineng Xu (ORCID: https://orcid.org/0000-0001-7195-4897)
- Suwen Wu
- Hongrong Hu
- Keith T. Flaherty (ORCID: https://orcid.org/0000-0002-3402-0478)
- Zexin Chen (ORCID: https://orcid.org/0000-0001-5790-5597)
- Shanshan Hu (ORCID: https://orcid.org/0000-0003-4904-0583)
- Yuanzhong Yang (ORCID: https://orcid.org/0000-0002-1458-3054)
- Zhen Zeng (ORCID: https://orcid.org/0000-0002-9055-217X)
- Haoqun Xie
- Yonggao Mou (ORCID: https://orcid.org/0000-0001-6045-503X)
- Gao Zhang (ORCID: https://orcid.org/0000-0001-8617-8886)
- Wanming Hu (ORCID: https://orcid.org/0000-0002-3632-1258)
- Yukun Chen (ORCID: https://orcid.org/0000-0002-9490-4435)
- Yuan Xie (ORCID: https://orcid.org/0000-0002-4901-146X)
- Yanjiao Yu
- Hao Duan
- Guangyin Zhao
- Wenjuan Ma
Institutions
- Rutgers, The State University of New Jersey (US)
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- Massachusetts General Hospital (US)
- West China Hospital of Sichuan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- University of Pennsylvania (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s12967-024-05658-x
- Citations
- 2
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province
- Basic and Applied Basic Research Foundation of Guangdong Province