Ringing the Changes: Effects of Heterocyclic Ring Size on Stereoselectivity in [(η5-C5Me5)RhCl], [(η5-C5Me5)IrCl] and [Ru(η6-cymene)Cl] Complexes of Chiral 3-Amino-1-Azacycles
Ring size-dependent diastereoselective coordination of unsymmetrical diamines containing one azacyclic nitrogen and one exocyclic nitrogen to [(η<sup>5</sup>-C<sub>5</sub>Me<sub>5</sub>)MCl]<sup>+</sup> cores where M = Rh, Ir and [Ru(η<sup>6</sup>-cymene)Cl]<sup>+</sup> is reported herein. Total stereoselectivity was observed with the six- and seven-membered azacycles, whereas the five-derivative proved poorly selective. All complexes were active for transfer hydrogenation but showed no enantioselectivity with prochiral ketones.
Authors
- Benjamin D. Ward (ORCID: https://orcid.org/0000-0003-1406-5940)
- Paul D. Newman (ORCID: https://orcid.org/0000-0002-1808-1211)
- Vladimir Y. Vladimirov (ORCID: https://orcid.org/0000-0002-3669-4804)
- Benson M. Kariuki (ORCID: https://orcid.org/0000-0002-8658-3897)
- Matheo Charrier-Chardin
Institutions
- Cardiff University (GB)
Publication Details
- Journal
- Molecules
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3390/molecules29194659
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cardiff University
- Engineering and Physical Sciences Research Council