Effect of Pregnyl (HCG) on Histological Structure of Testes in Albino Mice

Pregnyl is a placental hormone, produced mainly during the entire period of pregnancy, making it the vital sign for detecting pregnancy. The current study shed light on effect of Pregnyl on histological structure of testes in Albino mice. The study included 15 mice, and animals are divided into two groups. First group included five mice and second group included ten mice. They were placed in separate cages with continuous monitoring and cleaning throughout the study. First group was injected with Pregnyl at a concentration of 0.1 mg. /kg and the second group at a concentration of 0.2 mg/kg for a period of 30 days. After the end of the experiment, the animals were sacrificed, dissected, and their testicles were removed for the purpose of histological study. The outcome of this study shows that the animals in the two empirical groups which treated by Pregnyl showed changes in thickness of seminiferous tubules of testis wall and their shrinkage, as their manifestation becomes wavy and offbeat. furthermore, atrophy was noted in a few of seminiferous tubules, and the sloughing and exhaustion of some germ cells and their accumulating in lumen of seminiferous tubules. Additionally, degeneration was observed in some Sertolic cells.