Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy
The findings in this study indicate that distributed pathology in TLE may occur in brain networks connected to the hippocampal epicenter. Connectivity to these same networks was associated with improvement following RNS. A network approach to TLE may reveal therapeutic targets outside the traditional target in the hippocampus.
Authors
- Sheena Baratono (ORCID: https://orcid.org/0000-0003-4760-607X)
- Boris C. Bernhardt (ORCID: https://orcid.org/0000-0001-9256-6041)
- Aaron E. L. Warren (ORCID: https://orcid.org/0000-0001-6534-2800)
- Ella Sahlas (ORCID: https://orcid.org/0000-0002-7119-977X)
- Zhiqiang Zhang (ORCID: https://orcid.org/0000-0002-3993-7330)
- William Drew (ORCID: https://orcid.org/0000-0002-9178-8731)
- Raúl Rodríguez‐Cruces (ORCID: https://orcid.org/0000-0002-2917-1212)
- Judy Chen (ORCID: https://orcid.org/0009-0004-6332-9935)
- Jessica Royer (ORCID: https://orcid.org/0000-0002-4448-8998)
- Birgit Frauscher (ORCID: https://orcid.org/0000-0001-6064-1529)
- Yifei Weng (ORCID: https://orcid.org/0000-0003-3464-7067)
- Jordan DeKraker (ORCID: https://orcid.org/0000-0002-4093-0582)
- Shahin Tavakol (ORCID: https://orcid.org/0000-0002-7585-8963)
- Sara Larivière (ORCID: https://orcid.org/0000-0001-5701-1307)
- John D. Rolston (ORCID: https://orcid.org/0000-0002-8843-5468)
- Luis Concha (ORCID: https://orcid.org/0000-0002-7842-3869)
- Frédéric Schaper (ORCID: https://orcid.org/0000-0001-5487-0923)
- Neda Bernasconi (ORCID: https://orcid.org/0000-0001-9358-5703)
- Andrea Bernasconi (ORCID: https://orcid.org/0000-0001-9358-5703)
- Alexander Ngo (ORCID: https://orcid.org/0000-0002-8999-9388)
- Ke Xie (ORCID: https://orcid.org/0000-0002-7101-2493)
- Michael Fox (ORCID: https://orcid.org/0000-0001-8848-6399)
- Mae Morton-Dutton
Institutions
- Brigham and Women's Hospital (US)
- Montreal Neurological Institute and Hospital (CA)
- Harvard University (US)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Circuit Therapeutics (United States) (US)
- Institute of Neurobiology (BG)
- McGill University (CA)
- Nanjing University (CN)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1001/jamaneurol.2024.2952
- Citations
- 19
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.51