Immune checkpoint inhibitor induced hypophysitis: a specific disease of corticotrophs?
These data show that immune-related hypophysitis is a common complication of immune checkpoint inhibitor therapy. This may result in an imaging abnormality within the areas of the pituitary that are richest in corticotrophs. The endocrine consequence of this is a permanent defect in ACTH and, therefore, cortisol production.
Authors
- Fizzah Iqbal
- Jinny Jeffery (ORCID: https://orcid.org/0000-0002-7380-7476)
- Nishchil Patel
- Kagabo Hirwa
- Gemma Gardner
- Daniel Flanagan (ORCID: https://orcid.org/0000-0002-3346-6830)
- Kirsten Pearce
Institutions
- Morriston Hospital (GB)
- Plymouth Hospital (GB)
- University Hospitals Plymouth NHS Trust (GB)
- University of Plymouth (GB)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1530/ec-24-0223
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.72