Occurrence and predictors of laboratory abnormalities during outpatient parenteral antimicrobial therapy – A multicenter cohort study to inform laboratory test monitoring
While laboratory abnormalities are frequently observed during OPAT, they rarely lead to discontinuation of OPAT. Specific patient, treatment and laboratory characteristics were associated with the occurrence of laboratory abnormalities. Based on our results, we recommend a more personalized laboratory monitoring policy with less blood sampling.
Authors
- Jeroen Schouten (ORCID: https://orcid.org/0000-0001-9118-4420)
- Olivier Richel (ORCID: https://orcid.org/0009-0008-3923-1478)
- Reinier Akkermans (ORCID: https://orcid.org/0000-0003-0592-4563)
- Heiman Wertheim (ORCID: https://orcid.org/0000-0002-5003-5565)
- Jaap ten Oever (ORCID: https://orcid.org/0000-0003-2397-0125)
- Hester H. Stoorvogel (ORCID: https://orcid.org/0000-0002-5385-6764)
- Sofie Koenders
- Yvonne Kiers
- Marlies Hulscher
- Mirjam Tromp
- Suzan P. van Mens
- M. van Egmond
- Lars Peeters (ORCID: https://orcid.org/0009-0007-2667-5937)
- Tom Sprong
Institutions
- Radboud University Nijmegen (NL)
- Maastricht University Medical Centre (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Rijnstate Hospital (NL)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.jinf.2024.106301
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Pfizer