AteMeVs: An R package for the estimation of the average treatment effect with measurement error and variable selection for confounders

In causal inference, the estimation of the average treatment effect is often of interest. For example, in cancer research, an interesting question is to assess the effects of the chemotherapy treatment on cancer, with the information of gene expressions taken into account. Two crucial challenges in this analysis involve addressing measurement error in gene expressions and handling noninformative gene expressions. While analytical methods have been developed to address those challenges, no user-friendly computational software packages seem to be available to implement those methods. To close this gap, we develop an R package, called AteMeVs, to estimate the average treatment effect using the inverse-probability-weighting estimation method to handle data with both measurement error and spurious variables. This developed package accommodates the method proposed by Yi and Chen (2023) as a special case, and further extends its application to a broader scope. The usage of the developed R package is illustrated by applying it to analyze a cancer dataset with information of gene expressions.

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Publication Details

Journal
PLoS ONE
Published
2024-09-30
DOI
https://doi.org/10.1371/journal.pone.0296951
Citations
2
Primary Topic
Advanced Causal Inference Techniques
Type
article
Field-Weighted Citation Impact
1.42

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article

AteMeVs: An R package for the estimation of the average treatment effect with measurement error and variable selection for confounders

Li‐Pang Chen, Grace Y. Yi
2 citations
PLoS ONE
Advanced Causal Inference Techniques
1.42
article

AteMeVs: An R package for the estimation of the average treatment effect with measurement error and variable selection for confounders

Li‐Pang Chen, Grace Y. Yi
article en
2 citations

Abstract

In causal inference, the estimation of the average treatment effect is often of interest. For example, in cancer research, an interesting question is to assess the effects of the chemotherapy treatment on cancer, with the information of gene expressions taken into account. Two crucial challenges in this analysis involve addressing measurement error in gene expressions and handling noninformative gene expressions. While analytical methods have been developed to address those challenges, no user-friendly computational software packages seem to be available to implement those methods. To close this gap, we develop an R package, called AteMeVs, to estimate the average treatment effect using the inverse-probability-weighting estimation method to handle data with both measurement error and spurious variables. This developed package accommodates the method proposed by Yi and Chen (2023) as a special case, and further extends its application to a broader scope. The usage of the developed R package is illustrated by applying it to analyze a cancer dataset with information of gene expressions.

PLoS ONEVol. 19(9)
Western University (CA), National Chengchi University (TW)
Canada Research Chairs, National Science and Technology Council, Natural Sciences and Engineering Research Council of Canada
Good health and well-being
Openalex Percentile: Top 17%
Advanced Causal Inference Techniques
1.42
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