A preliminary indication that HLA-A*03:01 may be associated with visceral leishmaniasis development in people living with HIV in Ethiopia

Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. VL-HIV often leads to high rates of antileishmanial treatment failure and recurrent VL disease relapses. Considering the high prevalence of HIV and Leishmania in the Ethiopian population, preventing the progression of asymptomatic Leishmania infection to disease would be a valuable asset to VL disease control and to the clinical management of people living with HIV (PLWH). However, such a strategy requires good understanding of risk factors for VL development. In immunocompetent individuals living in Brazil, India, or Iran, the Human Leukocyte Antigen (HLA) gene region has been associated with VL development. We used NanoTYPE, an Oxford Nanopore Technologies sequencing-based HLA genotyping method, to detect associations between HLA genotype and VL development by comparing 78 PLWH with VL history and 46 PLWH that controlled a Leishmania infection, all living in a VL endemic region of North-West Ethiopia. We identified an association between HLA-A*03:01 and increased risk of VL development (OR = 3.89). These data provide candidate HLA alleles that can be further explored for inclusion in a potential Leishmania screen-and-treat strategy in VL endemic regions.

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Journal
PLoS neglected tropical diseases
Published
2024-09-30
DOI
https://doi.org/10.1371/journal.pntd.0012000
Citations
1
Primary Topic
Research on Leishmaniasis Studies
Type
article
Field-Weighted Citation Impact
0.54

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article

A preliminary indication that HLA-A*03:01 may be associated with visceral leishmaniasis development in people living with HIV in Ethiopia

Tadfe Bogale, Ermias Diro, Arega Yeshanew, Bart Cuypers et al.
1 citations
PLoS neglected tropical diseases
Research on Leishmaniasis Studies
0.54
article

A preliminary indication that HLA-A*03:01 may be associated with visceral leishmaniasis development in people living with HIV in Ethiopia

Tadfe Bogale, Ermias Diro, Arega Yeshanew, Bart Cuypers, Dagnew Mersha, Pieter Meysman, Kris Laukens, Kadrie Ramadan, Kasaye Sisay, Koert Ritmeijer, Hailemariam Beyene, Wim Adriaensen, Johan van Griensven, Saskia van Henten, Nicky de Vrij, Wim L. Cuypers, Thao‐Thy Pham, Rezika Mohammed, Roma Melkamu, Mekibib Kassa, Florian Vogt, Ann Ceulemans, Anke Van Hul, Romi Vandoren, Aderajew Kibret
article en
1 citations

Abstract

Human immunodeficiency virus (HIV) co-infection is a major challenge for visceral leishmaniasis (VL) control, particularly in Ethiopia where the incidence of both pathogens is high. VL-HIV often leads to high rates of antileishmanial treatment failure and recurrent VL disease relapses. Considering the high prevalence of HIV and Leishmania in the Ethiopian population, preventing the progression of asymptomatic Leishmania infection to disease would be a valuable asset to VL disease control and to the clinical management of people living with HIV (PLWH). However, such a strategy requires good understanding of risk factors for VL development. In immunocompetent individuals living in Brazil, India, or Iran, the Human Leukocyte Antigen (HLA) gene region has been associated with VL development. We used NanoTYPE, an Oxford Nanopore Technologies sequencing-based HLA genotyping method, to detect associations between HLA genotype and VL development by comparing 78 PLWH with VL history and 46 PLWH that controlled a Leishmania infection, all living in a VL endemic region of North-West Ethiopia. We identified an association between HLA-A*03:01 and increased risk of VL development (OR = 3.89). These data provide candidate HLA alleles that can be further explored for inclusion in a potential Leishmania screen-and-treat strategy in VL endemic regions.

PLoS neglected tropical diseasesVol. 18(9)
Australian National University (AU), Médecins Sans Frontières (UG), University of Antwerp (BE), University of Washington (US), UNSW Sydney (AU), Médecins Sans Frontières (NL), Instituut voor Tropische Geneeskunde (BE), University of Gondar (ET)
Fonds Wetenschappelijk Onderzoek, Universiteit Antwerpen, Vlaamse regering, Departement Economie, Wetenschap en Innovatie
Good health and well-being
Openalex Percentile: Top 28%
Research on Leishmaniasis Studies
0.54
DOIOpen Access PDFOpenAlex
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