Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study
Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders. Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.
Authors
- Yujue Wang
- Zongchang Li (ORCID: https://orcid.org/0000-0003-2741-4986)
- Ying He (ORCID: https://orcid.org/0000-0003-1603-9375)
- Xinbo Yang (ORCID: https://orcid.org/0000-0003-2695-6652)
- Sijie Zhang (ORCID: https://orcid.org/0000-0001-5974-2752)
- Qian Liu
- Huiqing Peng
- Lijun Ouyang
- Aijun Liao (ORCID: https://orcid.org/0000-0003-3792-703X)
- Liu Yuan
- Linlin Zhao
- Xiaogang Chen (ORCID: https://orcid.org/0009-0008-6870-4000)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Hunan Institute of Mental Health (CN)
Publication Details
- Journal
- Schizophrenia
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1038/s41537-024-00510-z
- Citations
- 6
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Central South University
- Xiangya Hospital, Central South University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities