Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis (RA)
Our findings suggest that the effect of low dose MTX treatment could serve to eliminate inflammation in RA patients through impairment of immune cell transmigration mediated by CXCR4.
Authors
- Daniel H. Park (ORCID: https://orcid.org/0000-0002-2773-320X)
- Meizhang Li
- Lingyuan Wu (ORCID: https://orcid.org/0000-0002-8548-6526)
- Bo Gao (ORCID: https://orcid.org/0000-0002-3254-8420)
- Haitham Abedelhakim
- Ming Zhang (ORCID: https://orcid.org/0000-0002-6032-7262)
- Lei Ding (ORCID: https://orcid.org/0000-0002-1619-9144)
Institutions
- Johns Hopkins University (US)
- Emory University (US)
- Yunnan University (CN)
- Kunming Medical University (CN)
- Johns Hopkins Medicine (US)
- University of Kansas Medical Center (US)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s13075-024-03403-9
- Citations
- 4
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Kunming Medical University
- Yunnan University