Causal relationships between leukocyte telomere length and female reproductive system diseases: a bidirectional Mendelian randomization study
Our findings substantiate the assumption that a genetically predicted longer LTL elevates the risk of endometriosis, leiomyoma of the uterus, and ovarian cysts, with no influence of RSDs on LTL. These findings contribute to establishing a causal link between LTL and RSDs, overcoming the constraints of earlier observational studies. They also imply that LTL could potentially serve as a biomarker for the occurrence of endometriosis, leiomyoma of the uterus, and ovarian cysts.
Authors
- He‐Feng Huang (ORCID: https://orcid.org/0000-0002-0195-985X)
- Junsen She
- Mengzhen Ding
- Ling-Xiang Wang
- Rui Liu (ORCID: https://orcid.org/0000-0001-6985-9129)
- Ling Gao (ORCID: https://orcid.org/0000-0003-1886-3931)
- Fei Guo
- Yuhang Long (ORCID: https://orcid.org/0000-0002-5751-805X)
- Haiyan Wu
- Xiaojing Wu (ORCID: https://orcid.org/0000-0002-6287-6812)
- Yi-Ning Cao
- Bokang Zhou
- S. H. Mao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Reproductive and Developmental Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1097/rd9.0000000000000108
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Zhejiang University
- Chinese Academy of Medical Sciences
- Shanghai Hospital Development Center
- Shanghai Clinical Research Center
- National Key Research and Development Program of China