Physical Exercise as a Modulator of the Levels of Leptin/Adiponectin Relation and Inflammation in Chronic Kidney Disease

Chronic kidney disease (CKD) is an important factor of loss of quality of life and high rates of morbidity and mortality, where cardiovascular diseases are the main responsible for this poorer prognosis. It is verified that CKD is associated with high inflammatory levels in the body, or that it seems to contribute to these cardiovascular events. Thus, CKD is characterized by a high inflammatory profile, as well as possibly a large imbalance in adipokines due to changes in body composition. Thus, adiponectin and leptin emerge as possible inflammatory modulators, although their popular effects are not completely elucidated. On the other hand, it is proven that physical exercise can be a great tool in the treatment of CKD and in the modulation of biomarkers, stimulating in an anti-inflammatory way and promoting an adjustment in the main causes of morbidity and mortality in this population. Thus, this review seeks to elucidate the role of exercise as a modulator of inflammation and the leptin/adiponectin relationship in order to contribute to the better quality of life of this population, in addition to demonstrating the important role that exercise can exert in modulation of these biomarkers, aiming to minimize the cardiovascular effects that these biomarkers exert on this population.