Regulation of plasma soluble receptors of TNF and IL-1 in patients with COVID-19 differs from that observed in sepsis
Our study reveals distinct regulation of plasma concentrations of soluble IL-1 receptors in COVID-19 and sepsis. Moreover, soluble TNF receptors 1 and 2 consistently rise in all conditions and show a positive correlation with disease severity in sepsis.
Authors
- Inge Grondman (ORCID: https://orcid.org/0000-0002-4687-9845)
- Valerie A. C. M. Koeken (ORCID: https://orcid.org/0000-0002-5783-9013)
- Evangelos J. Giamarellos‐Bourboulis (ORCID: https://orcid.org/0000-0003-4713-3911)
- Helga Dijkstra
- Isis Ricaño-Ponce (ORCID: https://orcid.org/0000-0002-7530-9526)
- Nico Janssen (ORCID: https://orcid.org/0000-0002-9629-8627)
- Heidi Lemmers
- Nikolaos Antonakos (ORCID: https://orcid.org/0000-0002-7552-5878)
- Eleni Antoniadou (ORCID: https://orcid.org/0009-0000-9916-8118)
- Anca Lelia Riza
- Job J. Engel (ORCID: https://orcid.org/0000-0002-8648-598X)
- Aline H. de Nooijer
- Frank L. van de Veerdonk (ORCID: https://orcid.org/0000-0002-1121-4894)
- Ioana Streață
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0003-0711-7466)
- Li Yang (ORCID: https://orcid.org/0000-0002-4710-059X)
- Athanasios Ziogas (ORCID: https://orcid.org/0000-0002-3731-4463)
- Tijmen van der Ent
- Mihai G. Netea
- Muhammed D. Aksu
Institutions
- Radboud University Nijmegen (NL)
- National and Kapodistrian University of Athens (GR)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- University of Medicine and Pharmacy of Craiova (RO)
- General Hospital of Athens G. Genimatas (GR)
- Radboud Institute for Molecular Life Sciences (NL)
- Centre for Individualised Infection Medicine (DE)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.jinf.2024.106300
- Citations
- 5
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Radboud Universitair Medisch Centrum
- HORIZON EUROPE Framework Programme
- European Research Council
- Horizon 2020
- H2020 European Research Council
- H2020 Marie Skłodowska-Curie Actions