Biomimetic cyclic-peptide based proton channels: bridging biological and synthetic systems

The translocation of protons across cellular membranes is crucial for various biological processes. This talk describes the development of biomimetic protein nanochannels that enable proton transport over micrometric distances. We utilize cyclic peptides that self-assemble into nanotubes, subsequently self-associating to form a hydrophilic channel wherein hydrogen bond chains, essential for proton transport, are established. This configuration emulates the proton transfer rates of natural protein channels and enhances stability in solution and under thermal stress. Our findings emphasize the potential of self-assembling peptides in bridging biological and synthetic systems for energy storage, biomedicine, and bioelectronics applications.