Conjugated-DNA hybrid materials for biosensing imaging and therapy applications

We developed an efficient solid-phase click reaction method to create π-conjugated-DNA amphiphilic molecules. Introducing hydrophilic DNA fragments improves the biocompatibility of π-conjugated materials and their recognition and response performance to bio-systems. π-Conjugated materials also provide optical signals for tracing and regulating the functions of DNA. This novel π-conjugated-DNA hybrid material system expands the application scope of π-conjugated materials in biomedicines. Specifically, my talk will include: (1) The development of π-conjugated-DNA amphiphilic molecules with reversible assembling properties provides a new design mechanism for the development of intelligent fluorescent bio-sensing materials; (2) Combining the encoding capability of DNA and the optical amplification properties of π-conjugated materials, amplified and highly multiplexed molecular imaging in single cells; (3) the application in light-gene combined therapy effectively improves the optical therapeutic effect of π-conjugated materials.