Low Doses of Tributyltin Chloride Induced Neurotoxicity in Male Rats

ABSTRACT: The environmental contaminant tributyltin chloride (TBTC), which is still present in commercially-collected items, is majorly utilized and continuously dispersed. It is one of the chemicals which disrupts the endocrine system and is exceedingly harmful to a variety of organisms. In this work, male rats were given TBTC at doses between 10 and 2000 μg/kg B.W. to determine its neurotoxicity. Animals have been separated into 8 equal groups and given the next daily doses of TBTC through oral gavage for a period of 45 days: 10, 50, 100, 250, 500, 1000, and 2000 μg/kg B.W. The effects of TBTC administration Along with disrupting the neurotransmitters as well as brain enzymes responsible for drug metabolism, TBTC elevated the indicators of the amyloid genic pathway, inflammation, and apoptosis. Histopathological analysis revealed that TBT exposure altered the brain tissue architecture. The neurotoxicity caused by high TBTC doses was more significant compared to that caused by low doses, and the impact was dose-dependent.