Intracellular delivery of antiviral shRNA using penetratin-based complexes effectively inhibits respiratory syncytial virus replication and host cell apoptosis
Penetratin effectively delivers shRNA targeting the RSV F gene, significantly reducing viral load and preventing apoptosis without toxicity. This approach surpasses Lipofectamine and shows potential for future therapeutic interventions, especially when combined with ribavirin, against RSV infection.
Authors
- Anahita Mojiri (ORCID: https://orcid.org/0000-0003-0936-5113)
- Haniyeh Abuei (ORCID: https://orcid.org/0000-0003-4552-8362)
- Ali Farhadi (ORCID: https://orcid.org/0000-0002-2271-670X)
- Mohammad Malekzadeh (ORCID: https://orcid.org/0000-0002-4247-906X)
- Faezeh Faghirabadi
Institutions
- Houston Methodist (US)
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Virology Journal
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s12985-024-02519-3
- Citations
- 8
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Shiraz University of Medical Sciences
- Shiraz University