Effect of high-dose multivitamin supplements on alanine aminotransferase elevations among adults living with HIV on antiretroviral therapy in Tanzania
High-dose RDA multivitamin supplementation increased the incidence of any mild to moderate ALT elevations among adults starting ART in Tanzania and the magnitude of the risk does not appear to differ by patient characteristics. However, immunocompromised PLWHA with CD4 T-cell counts < 100 cells/µL may experience greater risk of severe ALT elevations associated with the use of high-dose multivitamins. Although the study findings offer significant insights, it is essential to take into account limitations imposed by newer cART regimes.
Authors
- Wafaie Fawzi (ORCID: https://orcid.org/0000-0002-2908-600X)
- David Sando (ORCID: https://orcid.org/0000-0003-0246-8195)
- Claudia Hawkins (ORCID: https://orcid.org/0000-0001-7228-6317)
- Sabina Mugusi (ORCID: https://orcid.org/0000-0003-3367-0564)
- Christopher R. Sudfeld (ORCID: https://orcid.org/0000-0002-3203-3638)
- Ferdinand Mugusi (ORCID: https://orcid.org/0000-0001-7479-4913)
- Said Aboud
Institutions
- Northwestern University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- Harvard Global Health Institute (US)
Publication Details
- Journal
- BMC Nutrition
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s40795-024-00937-8
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- National Institute of Child Health and Human Development