PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release
We have identified PPARα and its agonists as therapeutic targets for controlling the neutrophil extracellular traps associated with high lipid metabolism. Results from preclinical models suggest that PPARα can limit mitochondrial oxidative stress, inhibit cGAS-STING-NF-κB signaling, and limit the release of neutrophil extracellular traps, thereby increasing the contact of anti-tumor leukocytes and hepatocellular cancer cells and limiting tumor growth.
Authors
- Nanhong Tang (ORCID: https://orcid.org/0000-0001-7495-5254)
- Dongjie Ye (ORCID: https://orcid.org/0000-0002-4118-5625)
- Banglun Pan (ORCID: https://orcid.org/0000-0003-4960-1512)
- Haijie Hong (ORCID: https://orcid.org/0000-0001-5454-3498)
- Yuxin Yao (ORCID: https://orcid.org/0000-0002-9358-7730)
- Yanling Chen (ORCID: https://orcid.org/0000-0002-6975-915X)
- Xiaoxia Zhang (ORCID: https://orcid.org/0009-0003-7031-9260)
- Xinran Cai
- Yue Luo
- Zhu Zhang
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101228
- Citations
- 7
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.64