Chronic myelomonocytic leukemia with <i>NPM1</i> mutation or acute myeloid leukemia?
The 2022 WHO revision and the ICC classification have recently modified the diagnostic criteria for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia. However, there is no consensus on whether CMML with NPM1 mutation (NPM1mut) should be diagnosed as AML. Nowadays, it is a subject of discussion because of its diagnostic and therapeutic implications. Therefore, we describe a case of a patient diagnosed with CMML NPM1mut and briefly review the literature to highlight the uncertainty about how to classify a CMML with NPM1 mutation. We emphasize the importance of a comprehensive molecular study, which is crucial to optimize the individualized treatment of patients, enabling them to access targeted therapies.
Authors
- Inés Zugasti (ORCID: https://orcid.org/0000-0002-7666-5055)
- Francesca Guijarro (ORCID: https://orcid.org/0000-0001-6376-0929)
- Sandra Castaño‐Díez (ORCID: https://orcid.org/0000-0001-9044-4665)
- Marta Gómez‐Hernando (ORCID: https://orcid.org/0009-0004-8490-9875)
- Mònica López‐Guerra (ORCID: https://orcid.org/0000-0002-5545-0178)
- Daniel Esteban (ORCID: https://orcid.org/0000-0001-8897-3170)
- Esther Carcelero
- Ares Guardia
- Jordi Esteve (ORCID: https://orcid.org/0000-0002-8056-648X)
- Gisela Riu-Viladoms (ORCID: https://orcid.org/0000-0002-8259-0811)
- Carlos Jiménez‐Vicente (ORCID: https://orcid.org/0000-0002-9548-4305)
- Álex Bataller (ORCID: https://orcid.org/0000-0002-6085-2745)
- Natalia Tovar (ORCID: https://orcid.org/0000-0001-5525-476X)
- Ana Triguero (ORCID: https://orcid.org/0000-0002-9895-9644)
- Irene López‐Oreja (ORCID: https://orcid.org/0000-0001-6756-1820)
- Marı́a Rozman (ORCID: https://orcid.org/0000-0002-2641-1110)
- Paola Charry (ORCID: https://orcid.org/0000-0002-4777-9643)
- Dolors Costa (ORCID: https://orcid.org/0000-0002-8276-3292)
- Marina Díaz‐Beyá (ORCID: https://orcid.org/0000-0001-9624-2597)
- Sı́lvia Beà (ORCID: https://orcid.org/0000-0001-7192-2385)
- Dolors Colomer (ORCID: https://orcid.org/0000-0001-7486-8484)
- José Ramón Álamo Moreno (ORCID: https://orcid.org/0000-0001-8579-082X)
- Albert Cortés‐Bullich (ORCID: https://orcid.org/0000-0002-6260-901X)
- Daniel Munárriz
- Víctor Torrecillas
- Lucía Mont‐de Torres
- Dolors Vela
Institutions
- Josep Carreras Leukaemia Research Institute (ES)
- Hospital General de Granollers (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- The Oncologist
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1093/oncolo/oyae246
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- European Commission
- Instituto de Salud Carlos III