Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy
Overall, this study elucidates TNBC pathogenesis closely linked to ferroptosis and identifies potential biomarkers in TNBC. Meanwhile, the study elucidates that Sal sensitizes TNBC to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy, regulated by PI3K/AKT/mTOR signaling pathways. Our findings provide a theoretical basis for applying Sal to treat TNBC.
Authors
- Tianhua Yan (ORCID: https://orcid.org/0000-0001-6124-8630)
- Lingpeng Zhu (ORCID: https://orcid.org/0000-0003-0762-4038)
- Yingdi Wang
- Guiqin Huang
- Yawen Cai
- Run Cheng (ORCID: https://orcid.org/0000-0003-3678-5949)
- Yu Fu (ORCID: https://orcid.org/0000-0001-9601-4498)
- Mingxing Miao
- Menghui Ren
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0002-1752-5482)
Institutions
- China Pharmaceutical University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.jare.2024.09.027
- Citations
- 60
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 25.14
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Fundamental Research Funds for the Central Universities