Stereotactic radiosurgery for 1–10 brain metastases to avoid whole-brain radiotherapy: Results of the CYBER-SPACE randomized phase 2 trial
The more sensitive SPACE sequence did not improve outcomes over MPRAGE. SRS with thorough monitoring and immediate re-treatment for new lesions decreases the need for WBRT and achieves low neurologic death rates. SRS should be considered a favorable alternative to WBRT for patients with 1-10 BM.
Authors
- Rami A. El Shafie (ORCID: https://orcid.org/0000-0002-1355-7882)
- Simon Höne
- Kristin Lang (ORCID: https://orcid.org/0000-0002-5355-3173)
- Thomas Welzel (ORCID: https://orcid.org/0000-0001-9960-3052)
- Farastuk Bozorgmehr (ORCID: https://orcid.org/0000-0001-8058-8884)
- Daniela Schmitt (ORCID: https://orcid.org/0000-0002-9657-0715)
- Laila König (ORCID: https://orcid.org/0000-0001-8402-6694)
- Sinem Erdem
- Meinhard Kieser (ORCID: https://orcid.org/0000-0003-2402-4333)
- Cornelia Jäkel
- Denise Bernhardt (ORCID: https://orcid.org/0000-0001-5231-9097)
- Sebastian Adeberg (ORCID: https://orcid.org/0000-0001-8463-514X)
- Jürgen Debus (ORCID: https://orcid.org/0000-0002-6411-4811)
- Stefan Rieken
- Annabella Schiele
- Ursula Nestle
- Fabian Weykamp (ORCID: https://orcid.org/0000-0003-1731-7090)
- Paul Thalmann
- Michael Thomas (ORCID: https://orcid.org/0000-0001-9511-055X)
- Anja Sander
- Adriane Lentz-Hommertgen
- Angela Paul
Institutions
- Philipps University of Marburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- TUM Klinikum (DE)
- Heidelberger Institut für Radioonkologie (DE)
- Kliniken Maria Hilf (DE)
- National Center for Tumor Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- German Center for Lung Research (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1093/neuonc/noae201
- Citations
- 15
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- Deutsches Krebsforschungszentrum
- Accuray
- Universitätsmedizin Göttingen
- Technische Universität München
- Deutschen Konsortium für Translationale Krebsforschung