Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons
This study investigates the regulation of circular RNAs (circRNAs) with Adenosine Deaminase RNA Specific B2 (ADARB2) enrichment specifically in inhibitory neurons. Using an integrated analysis combining high-throughput sequencing and bioinformatics approaches, we identified a group of circRNAs that are potentially enhanced by ADARB2. Our findings highlight the pivotal role of ADARB2 in circRNA synthesis within inhibitory neurons, likely through its specific binding to precursor RNAs, which facilitates circRNA biogenesis.
Authors
- Hongseok Ha (ORCID: https://orcid.org/0000-0002-0923-9187)
- Kwangsoo Kim (ORCID: https://orcid.org/0000-0002-4586-5062)
- Suwan Yu
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Computers in Biology and Medicine
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.compbiomed.2024.109212
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00