Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons

This study investigates the regulation of circular RNAs (circRNAs) with Adenosine Deaminase RNA Specific B2 (ADARB2) enrichment specifically in inhibitory neurons. Using an integrated analysis combining high-throughput sequencing and bioinformatics approaches, we identified a group of circRNAs that are potentially enhanced by ADARB2. Our findings highlight the pivotal role of ADARB2 in circRNA synthesis within inhibitory neurons, likely through its specific binding to precursor RNAs, which facilitates circRNA biogenesis.

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Publication Details

Journal
Computers in Biology and Medicine
Published
2024-09-28
DOI
https://doi.org/10.1016/j.compbiomed.2024.109212
Primary Topic
Circular RNAs in diseases
Type
article
Field-Weighted Citation Impact
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article

Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons

Hongseok Ha, Kwangsoo Kim, Suwan Yu
Computers in Biology and Medicine
Circular RNAs in diseases
article

Integrated analysis of circRNA regulation with ADARB2 enrichment in inhibitory neurons

Hongseok Ha, Kwangsoo Kim, Suwan Yu
article en

Abstract

This study investigates the regulation of circular RNAs (circRNAs) with Adenosine Deaminase RNA Specific B2 (ADARB2) enrichment specifically in inhibitory neurons. Using an integrated analysis combining high-throughput sequencing and bioinformatics approaches, we identified a group of circRNAs that are potentially enhanced by ADARB2. Our findings highlight the pivotal role of ADARB2 in circRNA synthesis within inhibitory neurons, likely through its specific binding to precursor RNAs, which facilitates circRNA biogenesis.

Computers in Biology and MedicineVol. 182
Seoul National University (KR), New Generation University College (ET), Seoul National University Hospital (KR)
Zero hunger
Openalex Percentile: Top 85%
Circular RNAs in diseases
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