Xanthine negatively regulates c‐MYC through the PI3K/AKT signaling pathway and inhibits the proliferation, invasion, and migration of breast cancer cells
Xanthine shows great potential for breast cancer treatment by targeting c-MYC via the PI3K/AKT signaling pathway. Our findings indicate that development of xanthine as a novel treatment option for breast cancer, which acts by influencing key oncogenic pathways involved in tumor progression, may be warranted.
Authors
- Limei Ai (ORCID: https://orcid.org/0000-0002-5339-8863)
- Aijia Zhang (ORCID: https://orcid.org/0009-0002-4709-4318)
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Asia-Pacific Journal of Clinical Oncology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1111/ajco.14125
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47