<i>poxtA</i> amplification and mutations in 23S rRNA confer enhanced linezolid resistance in <i>Enterococcus faecalis</i>
poxtA-carrying E. faecalis electrotransformants used two distinct mechanisms to resist linezolid selection pressure: at lower concentrations, strains prioritized increasing poxtA expression levels, while at higher concentrations, a combination of increased poxtA expression and mutations in 23S rRNA was observed.
Authors
- Xiang‐Dang Du (ORCID: https://orcid.org/0000-0001-7431-7607)
- Andrea Brenciani (ORCID: https://orcid.org/0000-0001-5191-3908)
- Xinxin Shan (ORCID: https://orcid.org/0009-0001-5747-8000)
- Štefan Schwarz (ORCID: https://orcid.org/0000-0002-6303-8212)
- Dexi Li
- Yanhong Shang
- Runhao Yu
- Chenhui Zou
- Chenglong Li (ORCID: https://orcid.org/0009-0009-1020-414X)
- Likuan Zhang
Institutions
- Marche Polytechnic University (IT)
- Anhui Agricultural University (CN)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Innovation Team (China) (HK)
- Henan Agricultural University (CN)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1093/jac/dkae342
- Citations
- 7
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China