Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B
Our novel CHB mouse model recapitulated the intrahepatic exhausted antiviral immunity in patients with CHB, which might be able to be reinvigorated by a hepatotropic TLR7 agonist.
Authors
- Daisuke Motooka (ORCID: https://orcid.org/0000-0002-4616-9608)
- Takahiro Kodama (ORCID: https://orcid.org/0000-0002-6250-1324)
- Akira Nishio (ORCID: https://orcid.org/0000-0003-1668-0779)
- Akihisa Fukushima
- Tetsuo Takehara (ORCID: https://orcid.org/0000-0001-5036-3457)
- Kazuhiro Murai (ORCID: https://orcid.org/0000-0001-8634-2922)
- Tatsuya Kanto (ORCID: https://orcid.org/0000-0003-4800-6754)
- Satoshi Shigeno
- Toru Okamoto (ORCID: https://orcid.org/0000-0003-4000-3102)
- Hayato Hikita (ORCID: https://orcid.org/0000-0003-2488-7315)
- Tomohide Tatsumi
Institutions
- Sumitomo Dainippon Pharma (Japan) (JP)
- National Center for Global Health and Medicine (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101412
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Japan Agency for Medical Research and Development
- Shionogi
- Nagoya City University