Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases
In summary, this study unravels the intricate cellular diversity within hepatic immune cell populations, highlighting the pivotal immune pathogenic role of the GZMK<sup>+</sup>CD4<sup>+</sup> T lymphocyte subset in ALD pathogenesis.
Authors
- Tingguo Zhang (ORCID: https://orcid.org/0000-0001-6337-5676)
- Mathias Heikenwälder (ORCID: https://orcid.org/0000-0002-3135-2274)
- Xiaoyu Xie (ORCID: https://orcid.org/0000-0002-8193-9487)
- Ding Xue (ORCID: https://orcid.org/0000-0002-8429-8136)
- Yawei Feng (ORCID: https://orcid.org/0000-0002-9184-7260)
- Detian Yuan (ORCID: https://orcid.org/0000-0002-7247-4526)
- Shiguan Wang (ORCID: https://orcid.org/0000-0001-9318-6382)
- Pierluigi Ramadori (ORCID: https://orcid.org/0000-0001-6581-9648)
- Haoran Wang (ORCID: https://orcid.org/0000-0001-7472-2303)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-3699-8672)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6218-1885)
- Xinying Li (ORCID: https://orcid.org/0000-0001-8462-8919)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-3957-8312)
- Bowen Xu (ORCID: https://orcid.org/0009-0004-1787-1299)
- Cuijuan Zhang
- Chao Gao (ORCID: https://orcid.org/0000-0001-8395-056X)
- Xueying Tan (ORCID: https://orcid.org/0000-0003-1493-8123)
- Ping Mi
- Shiyang Li
- Jinyuan Liang
- Xiaoyu Liu (ORCID: https://orcid.org/0009-0004-9164-5433)
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101411
- Citations
- 9
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.16