The recurrence of disease activity after ocrelizumab discontinuation in multiple sclerosis
We found focal inflammation after discontinuation of OCR in 4 (9.8 %) of the RRMS patients, of which 1 was radiologically confirmed. Our observations highlight that recurrence of focal inflammation seems low but discontinuation may not be appropriate for everyone. Further larger studies are important to determine the immune reconstitution therapy potential of OCR.
Authors
- Beatrijs Wokke (ORCID: https://orcid.org/0000-0002-2616-8464)
- Emma Tallantyre (ORCID: https://orcid.org/0000-0002-3760-6634)
- Jop Mostert (ORCID: https://orcid.org/0000-0003-3640-9935)
- Øivind Torkildsen (ORCID: https://orcid.org/0000-0001-5294-2866)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- E.M.E. Coerver (ORCID: https://orcid.org/0000-0001-5673-9996)
- Lauritz Schoof (ORCID: https://orcid.org/0009-0009-5895-8792)
- Anusha van Samkar (ORCID: https://orcid.org/0000-0001-6285-6945)
- Zoé van Kempen
- Bob W. van Oosten (ORCID: https://orcid.org/0000-0003-4536-6201)
- Kjell‐Morten Myhr (ORCID: https://orcid.org/0000-0002-0980-510X)
- Laura Hogenboom (ORCID: https://orcid.org/0009-0005-1230-1366)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
- Ide Smets (ORCID: https://orcid.org/0000-0001-8174-2898)
- P van Ruyven
- M. Wessels
Institutions
- Haukeland University Hospital (NO)
- University Hospital of Wales (GB)
- Erasmus MC (NL)
- Amsterdam Neuroscience (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Rijnstate Hospital (NL)
- Cardiff University (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.msard.2024.105900
- Citations
- 6
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.55