Noncoding Vault RNA1-1 Impairs Intestinal Epithelial Renewal and Barrier Function by Interacting With CUG-binding Protein 1
These findings indicate that elevated levels of vtRNA1-1 in EVs and mucosal tissues repress intestinal epithelial renewal and barrier function. Notably, this work reveals a novel role for dysregulation of the vtRNA1-1/CUGBP1 axis in the pathogenesis of gut mucosal disruption in critical illness.
Authors
- Jean‐Pierre Raufman (ORCID: https://orcid.org/0000-0002-6340-4382)
- Caroline G. Mallard
- Bridgette Warner (ORCID: https://orcid.org/0000-0002-0416-6177)
- Lan Xiao (ORCID: https://orcid.org/0000-0002-0391-6909)
- Rosemary A. Kozar (ORCID: https://orcid.org/0000-0002-9582-8622)
- Ting Chen (ORCID: https://orcid.org/0000-0003-0179-3586)
- Shweta Sharma (ORCID: https://orcid.org/0000-0002-6160-1331)
- Jian‐Ying Wang (ORCID: https://orcid.org/0000-0003-3002-1040)
- Min Seong Kwon
- Tingxi Yu
- Songah Chae
- Hee Kyoung Chung
Institutions
- University of Maryland, Baltimore (US)
- University of Maryland Medical Center (US)
- Baltimore VA Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101410
- Citations
- 6
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases